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Synthesis and structure of functionalized podands containing 4,7-dihydrotetrazolo[1,5-а]pyrimidine ring. Differently substituted dihydropyrimidine podands

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 3-oxobutanoate-containing polyethers with benzaldehyde and 5-aminotetrazole in the presence of polyphosphoric acid was used to synthesize podands containing two terminal tetrazolo[1,5-а]dihydropyrimidine groups. Byproducts were isolated and identified as podands containing different substituents – one 4,7-dihydrotetrazolo[1,5-а]pyrimidine ring system and a free hydroxy group at the other terminus of the polyether chain. Analogous differently substituted podands, including one 3,4-dihydropyrimidine-2(1H)-thione moiety, were isolated from the reactions of 3-oxobutanoate-containing polyethers with benzaldehyde and thiourea.

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This work was performed with financial support from the Russian Science Foundation (project 15-13-00077-P).

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg, 620990, Russia

    Elena S. Filatova, Olga V. Fedorova, Pavel A. Slepukhin, Gennady L. Rusinov & Valery N. Charushin

  2. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002, Russia

    Elena S. Filatova, Pavel A. Slepukhin, Gennady L. Rusinov & Valery N. Charushin

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  1. Elena S. Filatova
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  2. Olga V. Fedorova
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  3. Pavel A. Slepukhin
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  4. Gennady L. Rusinov
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  5. Valery N. Charushin
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Correspondence to Elena S. Filatova.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(10), 971–976

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Filatova, E.S., Fedorova, O.V., Slepukhin, P.A. et al. Synthesis and structure of functionalized podands containing 4,7-dihydrotetrazolo[1,5-а]pyrimidine ring. Differently substituted dihydropyrimidine podands. Chem Heterocycl Comp 54, 971–976 (2018). https://doi.org/10.1007/s10593-018-2373-0

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  • DOI: https://doi.org/10.1007/s10593-018-2373-0

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