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An effective method for the synthesis of 1,5-disubstituted 4-halo-1H-1,2,3-triazoles from magnesium acetylides

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Chemistry of Heterocyclic Compounds Aims and scope

A simple one-pot two-stage method for the synthesis of disubstituted 4-chloro-, 4-bromo-, and 4-iodo-1,2,3-triazoles from terminal alkynes and organic azides is proposed.

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The study was carried out with the financial support of the Russian Foundation for Basic Research in the framework of the scientific project No. 18-33-00075 mole_a.

The work was carried out using the equipment of the Collective Use Center “Bioorganic” of the Russian Academy of Sciences, supported by the Russian Ministry of Education and Science (agreement identifier RFMEFI62117X0018).

Author information

Authors and Affiliations

  1. Moscow M. V. Lomonosov State University, 1, Build. 3, Leninskie Gory, Moscow, 119991, Russia

    Iuliia V. Karsakova

  2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russia

    Alexander Yu. Smirnov & Mikhail S. Baranov

  3. Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow, 117997, Russia

    Mikhail S. Baranov

Authors
  1. Iuliia V. Karsakova
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  2. Alexander Yu. Smirnov
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  3. Mikhail S. Baranov
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Corresponding author

Correspondence to Alexander Yu. Smirnov.

Additional information

Supporting information file containing 1H and 13C NMR spectra of the synthesized compounds is available at the journal website at http://link.springer.com/journal/10593.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(7), 755–757

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Karsakova, I.V., Smirnov, A.Y. & Baranov, M.S. An effective method for the synthesis of 1,5-disubstituted 4-halo-1H-1,2,3-triazoles from magnesium acetylides. Chem Heterocycl Comp 54, 755–757 (2018). https://doi.org/10.1007/s10593-018-2343-6

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  • DOI: https://doi.org/10.1007/s10593-018-2343-6

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