Ethyl 2-oxo-3-(4-oxo-4Н-chromen-2-yl)propanoates reacted with S-methylisothiosemicarbazide hydroiodide at the ethoxalyl group, forming 3-methylsulfanyl-6-[(4-oxo-4Н-chromen-2-yl)methyl]-1,2,4-triazin-5(2H)-ones upon refluxing in pyridine (40–50% yields) or 6-[(4-oxo-4Н-chromen-2-yl)methyl]-1,2,4-triazine-3,5(2Н,4Н)-diones when refluxed in ethanol (37–74% yields).
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This work received financial support from the Russian Foundation for Basic Research (grant 17-03-00340).
Analytical studies were performed at the Collective Access Center “Spectroscopy and analysis of organic compounds” of the Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences and at the Laboratory of Complex Investigations and Expert Evaluation of Organic Materials of the Ural Federal University named after the first President of Russia B. N. Yeltsin.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(7), 696–699
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Vetyugova, D.A., Nashtatik, N.S., Safrygin, A.V. et al. The reaction of ethyl 2-oxo-3-(4-oxo-4Н-chromen-2-yl)propanoates with S-methylisothiosemicarbazide hydroiodide. Chem Heterocycl Comp 54, 696–699 (2018). https://doi.org/10.1007/s10593-018-2334-7
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DOI: https://doi.org/10.1007/s10593-018-2334-7