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Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities

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Chemistry of Heterocyclic Compounds Aims and scope

A new series of 4,4'-(3,5-diphenethylbenzo[1,2-b:5,4-b']difuran-2,6-diyl)bis(N-(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2-b:5,4-b']difuran-2,6-diyl)diethanone O,O'-diacetyl dioxime and substituted isothiocyanates under conventional and microwave irradiation conditions. The obtained products were subjected to in vitro antibacterial and antimycobacterial activity tests. Some of the compounds exhibited noteworthy antibacterial activity against Bacillus subtilis (+ve) and Pseudomonas aeruginosa (-ve) strains and antimycobacterial activity against Mycobacterium bovis strain.

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The authors are grateful to the Head of Department of Chemistry, Osmania University, Hyderabad and IICT, Hyderabad for providing analytical and biological facilities. D. Ashok is also thankful to DST, PURSE-II programme, Osmania University for the financial assistance. Ananda Rao thanks CSIR, New Delhi, India for the research associate fellowship.

The authors are thankful to Chemveda Life Sciences Pvt. Ltd., IDA, Uppal, and Hyderabad for providing laboratory facilities.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, Telangana, 500085, India

    N. H. Kumar Baba

  2. Chemveda Life Sciences India Pvt. Ltd., I.D.A. Uppal, Hyderabad, Telangana, 500039, India

    N. H. Kumar Baba

  3. Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Dongamanti Ashok & Boddu Ananda Rao

  4. Department of Chemistry, Satavahana University, Karimnagar, Telangana, 505001, India

    Madderla Sarasija

  5. Department of Chemistry, Anurag Group of Institutions, Hyderabad, Telangana, 500088, India

    Nandula Y. S. Murthy

Authors
  1. N. H. Kumar Baba
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  2. Dongamanti Ashok
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  3. Boddu Ananda Rao
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  4. Madderla Sarasija
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  5. Nandula Y. S. Murthy
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Corresponding author

Correspondence to Dongamanti Ashok.

Additional information

The Supplementary information file, containing IR, 1H NMR, 13C NMR, and mass spectral data of compounds 3–6 and 8a–h, is available at the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(6), 658–663

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Kumar Baba, N.H., Ashok, D., Rao, B.A. et al. Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities. Chem Heterocycl Comp 54, 658–663 (2018). https://doi.org/10.1007/s10593-018-2323-x

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  • DOI: https://doi.org/10.1007/s10593-018-2323-x

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