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An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine

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Chemistry of Heterocyclic Compounds Aims and scope

An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block.

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This research was financially supported by The National Key Technology R&D Program (No. 2015BAK45B00). We also thank the Laboratory of Organic Functional Molecules, the Sino-French Institute of ECNU for support.

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Authors and Affiliations

  1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China

    Yu-Liu Zhang, Cheng-Tao Xu, Ting Liu & Yu Luo

  2. Suzhou Highfine Biotech Co., Ltd., Suzhou, 215129, P. R. China

    Yong Zhu

Authors
  1. Yu-Liu Zhang
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  2. Cheng-Tao Xu
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  3. Ting Liu
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  4. Yong Zhu
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  5. Yu Luo
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Correspondence to Yu Luo.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(6), 638–642

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Zhang, YL., Xu, CT., Liu, T. et al. An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine. Chem Heterocycl Comp 54, 638–642 (2018). https://doi.org/10.1007/s10593-018-2320-0

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  • DOI: https://doi.org/10.1007/s10593-018-2320-0

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