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Synthesis and evaluation of some novel 3-hetarylindole derivatives as antimicrobial and antioxidant agents

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Chemistry of Heterocyclic Compounds Aims and scope

In a continuation of our program to develop a new class of antimicrobial and antioxidant agents, 13 novel 3-substituted indole derivatives incorporating biologically active heterocycles were synthesized and evaluated for their in vitro antimicrobial activity. Among the synthesized compounds, 3-(7H-imidazo[2,1-c][1,2,4]triazol-5-yl)-1H-indole showed activity against E. faecalis equal to that of ampicillin and 50% higher activity than ampicillin against S. aureus and B. subtilis. Also, 3-(7H-imidazo[2,1-c][1,2,4]triazol-5-yl)-1H-indole was found to exhibit strong in vitro antifungal activity against Candida albicans, Aspergillus niger, and Penicillium sp. The antioxidant activity of the obtained indole derivatives was also studied using 2,2'-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid).

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Scheme 2.

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All of the tested microorganisms were selected based on their clinical and pharmacological importance and were kindly provided by Dr. Metwally, Prof. of Microbiology, Botany Department, Tanta University, Egypt.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria St., Mansoura, 35516, Egypt

    Ahmed El-Mekabaty

  2. Botany Department, Faculty of Science, Mansoura University, El-Gomhoria St., Mansoura, 35516, Egypt

    Hamed M. El-Shora

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  1. Ahmed El-Mekabaty
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  2. Hamed M. El-Shora
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Correspondence to Ahmed El-Mekabaty.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(6), 618–624

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El-Mekabaty, A., El-Shora, H.M. Synthesis and evaluation of some novel 3-hetarylindole derivatives as antimicrobial and antioxidant agents. Chem Heterocycl Comp 54, 618–624 (2018). https://doi.org/10.1007/s10593-018-2317-8

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