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Annulation of tetrahydro-2-pyrimidinone with α-iodo ketones

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Chemistry of Heterocyclic Compounds Aims and scope

The first annulated heterocyclic derivatives of tetrahydro-2-pyrimidin-2(1H)-one were synthesized in one preparative step on the basis of a solventless three-component reaction of tetrahydro-2-pyrimidin-2(1H)-one with 1-iodopropan-2-one, 2-iodo-1-phenylethan-1-one, 2-iodo-1-(thiophen-2-yl)ethan-1-one, or 1,3-diiodopropan-2-one and elemental iodine in the absence of a base.

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The main results were obtained using the material and technical base of the Baikal Analytical Center for Collective Use of the Siberian Branch of the RAS.

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  1. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk, 664033, Russia

    Ivan А. Dorofeev, Ludmila G. Shagun, Larisa V. Zhilitskaya, Nina O. Yarosh & Ludmila I. Larina

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  1. Ivan А. Dorofeev
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  2. Ludmila G. Shagun
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  3. Larisa V. Zhilitskaya
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  4. Nina O. Yarosh
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  5. Ludmila I. Larina
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Correspondence to Ludmila G. Shagun.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(5), 550–553

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Dorofeev, I.А., Shagun, L.G., Zhilitskaya, L.V. et al. Annulation of tetrahydro-2-pyrimidinone with α-iodo ketones. Chem Heterocycl Comp 54, 550–553 (2018). https://doi.org/10.1007/s10593-018-2302-2

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  • DOI: https://doi.org/10.1007/s10593-018-2302-2

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