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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 3, pp 355–361 | Cite as

Three-component hetero-domino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes to afford 1,3-dipropargylimidazolidines

  • Lu Sun
  • Mengying Wu
  • Xi Huang
  • Jiayi WangEmail author
  • Gonghua Song
Article

A novel and efficient approach to the synthesis of 1,3-dipropargylimidazolidines via a hetero-domino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes has been reported. The transformation provides a useful method for the synthesis of imidazolidine derivatives.

Keywords

1,3-dipropargylimidazolidines A3-coupling copper catalysis cyclization hetero-domino reaction three-component reaction 

Notes

Financial support for this work from the National Key R&D Program (Grant No. 2017YFD0200504), the National Natural Science Foundation of China (grant No. 21572060), and the Shanghai Key Laboratory of Catalysis Technology for Polyolefins (LCTP-201301) is gratefully acknowledged.

Supplementary material

10593_2018_2273_MOESM1_ESM.pdf (3.1 mb)
ESM 1 (PDF 3193 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Lu Sun
    • 1
  • Mengying Wu
    • 1
  • Xi Huang
    • 1
  • Jiayi Wang
    • 1
    Email author
  • Gonghua Song
    • 1
  1. 1.Shanghai Key Laboratory of Chemical Biology, School of PharmacyEast China University of Science and TechnologyShanghaiPeople’s Republic of China

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