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Nickel-catalyzed multicomponent heterocyclization of 2,4-pentanedione to sulfanylmethyl-1H-pyrazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A one-pot synthesis of new sulfanylmethyl-substituted 3,5-dimethyl-1H-pyrazoles with fungicidal activity was based on a nickelcatalyzed four-component condensation of 2,4-pentanedione with formaldehyde, thiols, and hydrazine hydrate.

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This work received financial support from the Russian Foundation for Basic Research and the Academy of Sciences of the Republic of Bashkortostan (project 17-43-020292 r_a), the Grants Council of the President of Russian Federation (grant NSh-5240.2018.3) and within the framework of the Project part of the State Assignment АААА-А17-117012610060-7.

Structural characterization of the obtained compounds was performed on the equipment at the Regional Collective Use Center “Agidel”.

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Authors and Affiliations

  1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Oktyabrya Ave., Ufa, 450075, Russia

    Nail S. Akhmadiev, Vnira R. Akhmetova & Askhat G. Ibragimov

  2. Ufa Institute of Biology, Russian Academy of Sciences, 69 Oktyabrya Ave., Ufa, 450054, Russia

    Taisiya F. Boiko

Authors
  1. Nail S. Akhmadiev
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  2. Vnira R. Akhmetova
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  3. Taisiya F. Boiko
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  4. Askhat G. Ibragimov
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Correspondence to Vnira R. Akhmetova.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(3), 344–350

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Akhmadiev, N.S., Akhmetova, V.R., Boiko, T.F. et al. Nickel-catalyzed multicomponent heterocyclization of 2,4-pentanedione to sulfanylmethyl-1H-pyrazoles. Chem Heterocycl Comp 54, 344–350 (2018). https://doi.org/10.1007/s10593-018-2271-5

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  • DOI: https://doi.org/10.1007/s10593-018-2271-5

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