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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 3, pp 344–350 | Cite as

Nickel-catalyzed multicomponent heterocyclization of 2,4-pentanedione to sulfanylmethyl-1H-pyrazoles

  • Nail S. Akhmadiev
  • Vnira R. AkhmetovaEmail author
  • Taisiya F. Boiko
  • Askhat G. Ibragimov
Article

A one-pot synthesis of new sulfanylmethyl-substituted 3,5-dimethyl-1H-pyrazoles with fungicidal activity was based on a nickelcatalyzed four-component condensation of 2,4-pentanedione with formaldehyde, thiols, and hydrazine hydrate.

Keywords

hydrazine hydrate 2,4-pentanedione sulfanylmethyl-substituted pyrazoles thiols catalysis fungicidal activity multicomponent reactions 

Notes

This work received financial support from the Russian Foundation for Basic Research and the Academy of Sciences of the Republic of Bashkortostan (project 17-43-020292 r_a), the Grants Council of the President of Russian Federation (grant NSh-5240.2018.3) and within the framework of the Project part of the State Assignment АААА-А17-117012610060-7.

Structural characterization of the obtained compounds was performed on the equipment at the Regional Collective Use Center “Agidel”.

Supplementary material

10593_2018_2271_MOESM1_ESM.pdf (557 kb)
ESM 1 (PDF 557 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Nail S. Akhmadiev
    • 1
  • Vnira R. Akhmetova
    • 1
    Email author
  • Taisiya F. Boiko
    • 2
  • Askhat G. Ibragimov
    • 1
  1. 1.Institute of Petrochemistry and CatalysisRussian Academy of SciencesUfaRussia
  2. 2.Ufa Institute of BiologyRussian Academy of SciencesUfaRussia

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