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Activation-free one-pot alkynylation–cyclization synthesis of 2-substituted 4-azaindoles and indoles

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Chemistry of Heterocyclic Compounds Aims and scope

2-Substituted 4-azaindoles and indoles are rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation–cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.

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The authors cordially thank the Fonds der Chemischen Industrie for financial support (scholarship for Timo Lessing).

The authors cordially thank the microanalytical laboratory of the Institut für Medizinische und Pharmazeutische Chemie at the Heinrich-Heine-Universität Düsseldorf for the elemental analyses measurment.

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Authors and Affiliations

  1. Institut für Organische Chemie und Makromolekulare Chemie, Lehrstuhl für Organische Chemie, Heinrich-Heine-Universität Düsseldorf, 1 Universitätsstraße, D-40225, Düsseldorf, Germany

    Timo Lessing & Thomas J. J. Müller

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  1. Timo Lessing
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  2. Thomas J. J. Müller
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Correspondence to Thomas J. J. Müller.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(3), 334–338

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Lessing, T., Müller, T.J.J. Activation-free one-pot alkynylation–cyclization synthesis of 2-substituted 4-azaindoles and indoles. Chem Heterocycl Comp 54, 334–338 (2018). https://doi.org/10.1007/s10593-018-2269-z

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  • DOI: https://doi.org/10.1007/s10593-018-2269-z

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