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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 3, pp 292–301 | Cite as

Metal-catalyzed privileged 2- and 3-functionalized indole synthesis*

  • Arun K. SinhaEmail author
  • Danish Equbal
  • Mane Rajendra Uttam
Article

This review summarizes the metal-catalyzed approaches for the synthesis of privileged 2- and 3-functionalized indoles via the Fischer indole synthesis, cycloaddition reaction, C–H activation reaction, and coupling reactions. Polycyclic derivatives of indole are also listed including triptamine-based pharmaceutical 5-HT1D agonist L 775,606. Some important mechanism studies are described in details in this review. The review covers literature for the last 20 years.

Keywords

bioactive indole scaffolds functionalized indole heterocycles indole C–H activation metal catalysis 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Arun K. Sinha
    • 1
    • 2
    Email author
  • Danish Equbal
    • 1
  • Mane Rajendra Uttam
    • 1
    • 3
  1. 1.Medicinal and Process Chemistry DivisionCSIR-Central Drug Research InstituteLucknowIndia
  2. 2.Academy of Scientific and Innovative ResearchNew DelhiIndia
  3. 3.Department of Medicinal ChemistryNational Institute of Pharmaceutical Education and ResearchRaebareliIndia

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