This review summarizes the metal-catalyzed approaches for the synthesis of privileged 2- and 3-functionalized indoles via the Fischer indole synthesis, cycloaddition reaction, C–H activation reaction, and coupling reactions. Polycyclic derivatives of indole are also listed including triptamine-based pharmaceutical 5-HT1D agonist L 775,606. Some important mechanism studies are described in details in this review. The review covers literature for the last 20 years.
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* CDRI Communication No. 9650.
Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(3), 292–301
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Sinha, A.K., Equbal, D. & Uttam, M.R. Metal-catalyzed privileged 2- and 3-functionalized indole synthesis*. Chem Heterocycl Comp 54, 292–301 (2018). https://doi.org/10.1007/s10593-018-2263-5
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DOI: https://doi.org/10.1007/s10593-018-2263-5