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Furan ring transformation as key stage in the synthesis of 5H,12H-benzo[4,5]imidazo[1,2-a]pyrrolo[1,2-d]pyrazines

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Chemistry of Heterocyclic Compounds Aims and scope

We report the first synthesis of new condensed benzimidazole derivatives – 5H,12H-benzo[4,5]imidazo[1,2-a]pyrrolo[1,2-d]pyrazines, based on furan ring transformation in 1-[(5-alkylfuran-2-yl)methyl]-2-(chloromethyl)benzimidazoles. Two routes are presented for the formation of pyrrolopyrazine system, with different order of steps for the introduction of amino group and opening of the furan ring.

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This study received financial support from the Ministry of Education and Science of the Russian Federation (contract 4.6087.2017/BCh).

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Authors and Affiliations

  1. Kuban State Technological University, 2 Moskovskaya St., Krasnodar, 350072, Russia

    Tat’yana A. Stroganova, Vladimir K. Vasilin & Gennady D. Krapivin

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  1. Tat’yana A. Stroganova
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  2. Vladimir K. Vasilin
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  3. Gennady D. Krapivin
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Correspondence to Tat’yana A. Stroganova.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(2), 188–196

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Stroganova, T.A., Vasilin, V.K. & Krapivin, G.D. Furan ring transformation as key stage in the synthesis of 5H,12H-benzo[4,5]imidazo[1,2-a]pyrrolo[1,2-d]pyrazines. Chem Heterocycl Comp 54, 188–196 (2018). https://doi.org/10.1007/s10593-018-2253-7

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  • DOI: https://doi.org/10.1007/s10593-018-2253-7

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