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Interaction of condensed tetrahydropyrido[4,3-d]pyrimidin-4-ones with dehydrobenzene – synthesis of 6-vinylpyrimidinones fused with five-membered heterocycle containing two or three heteroatoms

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction between dehydrobenzene and tetrahydropyrido[4,3-d]pyrimidin-4-ones condensed with isoxazole, thiazole, thiadiazole, or triazole rings resulted in Hofmann cleavage of the tetrahydropyridine moiety with the formation of 6-vinyl-substituted pyrimidones fused with the corresponding azole rings.

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This study received financial support from Project RUDN 5-100 for years 2016–2020 and the Russian Foundation for Basic Research (grant 17-03-00605).

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Authors and Affiliations

  1. RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russia

    Aleksey V. Varlamov, Natalia I. Guranova, Tatiana N. Borisova, Elena A. Sorokina & Leonid G. Voskressensky

  2. North Caucasus Federal University, 1 Pushkina St., Stavropol, 355009, Russia

    Alexander V. Aksenov

Authors
  1. Aleksey V. Varlamov
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  2. Natalia I. Guranova
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  3. Tatiana N. Borisova
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  4. Elena A. Sorokina
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  5. Alexander V. Aksenov
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  6. Leonid G. Voskressensky
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Corresponding author

Correspondence to Leonid G. Voskressensky.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(2), 173–176

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Varlamov, A.V., Guranova, N.I., Borisova, T.N. et al. Interaction of condensed tetrahydropyrido[4,3-d]pyrimidin-4-ones with dehydrobenzene – synthesis of 6-vinylpyrimidinones fused with five-membered heterocycle containing two or three heteroatoms. Chem Heterocycl Comp 54, 173–176 (2018). https://doi.org/10.1007/s10593-018-2250-x

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  • DOI: https://doi.org/10.1007/s10593-018-2250-x

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