Interaction of condensed tetrahydropyrido[4,3-d]pyrimidin-4-ones with dehydrobenzene – synthesis of 6-vinylpyrimidinones fused with five-membered heterocycle containing two or three heteroatoms
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The reaction between dehydrobenzene and tetrahydropyrido[4,3-d]pyrimidin-4-ones condensed with isoxazole, thiazole, thiadiazole, or triazole rings resulted in Hofmann cleavage of the tetrahydropyridine moiety with the formation of 6-vinyl-substituted pyrimidones fused with the corresponding azole rings.
Keywords
arynes azole ring dehydrobenzene pyridopyrimidinones vinyl-substituted pyrimidinones annulation Hofmann cleavageNotes
This study received financial support from Project RUDN 5-100 for years 2016–2020 and the Russian Foundation for Basic Research (grant 17-03-00605).
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