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Synthesis of 1,2,3-triazoles linked into chains with other carbo- and heterocycles by a reaction between β-azolyl enamines and azides

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Chemistry of Heterocyclic Compounds Aims and scope

The reactions of β-azolyl enamines with azides proceeded under solvent-free conditions in the absence of base at 110°С by one of the possible routes, selectively forming 1,4-disubstituted 1,2,3-triazoles. The proposed reaction mechanism includes cycloaddition of the starting reagents, leading to 1,2,3-triazoline intermediates, followed by elimination of dimethylamine and the formation of aromatic triazole ring.

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This work received financial support from the Russian Science Foundation (grant 15-13-10031).

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002, Russia

    Ilya V. Efimov, Nikolai A. Beliaev, Vasiliy A. Bakulev & Tetyana V. Beryozkina

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  1. Ilya V. Efimov
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  2. Nikolai A. Beliaev
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  3. Vasiliy A. Bakulev
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  4. Tetyana V. Beryozkina
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Correspondence to Tetyana V. Beryozkina.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(2), 167–172

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Efimov, I.V., Beliaev, N.A., Bakulev, V.A. et al. Synthesis of 1,2,3-triazoles linked into chains with other carbo- and heterocycles by a reaction between β-azolyl enamines and azides. Chem Heterocycl Comp 54, 167–172 (2018). https://doi.org/10.1007/s10593-018-2249-3

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  • DOI: https://doi.org/10.1007/s10593-018-2249-3

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