Chemistry of Heterocyclic Compounds

, Volume 54, Issue 2, pp 122–124 | Cite as

Open image in new window Synthesis of 1H-pyrrol-2(5H)-ones (microreview)

  • Seyed Sajad Sajadikhah

IntroductionOpen image in new window

The ubiquity of 1H-pyrrol-2(5H)-ones in pharmaceuticals and natural products makes them attractive targets for organic synthesis. Dihydropyrrol-2-ones display a broad spectrum of biological activity as antitumor and anticancer agents, apoptosis signal-regulating kinase 1 (ASK1) inhibitors, and inhibitors of human cytosolic carbonic anhydrase isozymes.1 Dihydropyrrol-2-one moiety is also found in various natural bioactive products including C-17 lactambearing limonoids, PI-091 and jatropham, oteromycin, myceliothermophin, codinaeopsin, and talaroconvolutin B.2


Financial support from the Research Council of the Payame Noor University is gratefully acknowledged.


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Authors and Affiliations

  1. 1.Department of ChemistryPayame Noor UniversityTehranIran

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