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Chemistry of Heterocyclic Compounds

, Volume 53, Issue 12, pp 1324–1329 | Cite as

Synthesis and tuberculostatic activity of functionalized pyrazoles derived from (trifluoromethyl)pyrazole containing a hydrazone group

  • Denis N. BazhinEmail author
  • Yulia S. Kudyakova
  • Aleksandra Ya. Onoprienko
  • Pavel A. Slepukhin
  • Yanina V. Burgart
  • Victor I. Saloutin
Article

The condensation of 5-(1-hydrazinylideneethyl)-3-(trifluoromethyl)-1H-pyrazole with trimethyl orthoacetate, dimethylformamide dimethyl acetal, and aryl thioisocyanates resulted in a series of functionalized pyrazoles and their tuberculostatic activity was studied.

Keywords

hydrazones pyrazole thiosemicarbazides condensation 

Notes

The work was performed with financial support from the Russian Foundation for Basic Research (project No. 16-33-00115 mol_a).

Supplementary material

10593_2018_2214_MOESM1_ESM.pdf (845 kb)
ESM 1 (PDF 845 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Denis N. Bazhin
    • 1
    • 2
    Email author
  • Yulia S. Kudyakova
    • 1
  • Aleksandra Ya. Onoprienko
    • 2
  • Pavel A. Slepukhin
    • 1
    • 2
  • Yanina V. Burgart
    • 1
  • Victor I. Saloutin
    • 1
  1. 1.Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of SciencesYekaterinburgRussia
  2. 2.Ural Federal University named after the first President of Russia B. N. YeltsinYekaterinburgRussia

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