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Chemistry of Heterocyclic Compounds

, Volume 53, Issue 12, pp 1302–1309 | Cite as

A study of plant coumarins 16*. Synthesis and transformations of 7-alkynylcoumarins

  • Alla V. Lipeeva
  • Elvira E. ShultsEmail author
Article

7-Alkynyl-substituted coumarins were synthesized by a Sonogashira reaction of 6-substituted 7-(trifluoromethylsulfonyloxy)coumarins with terminal acetylenes. The reaction of 7-ethynyl-substituted coumarins with azidobenzoic acids in the presence of copper(II) sulfate and sodium ascorbate was used to synthesize the respective 7-[(1-carboxyphenyl)-1H-1,2,3-triazol-4-yl]coumarins.

Keywords

arylalkynes coumarins 1,2,3-triazoles CuААС reaction Sonogashira reaction 

Notes

The work was performed with financial support from the Russian Foundation for Basic Research (project No. 16-5344027) and the Russian Science Foundation (project No. 17-73-10099). The authors would like to express their gratitude to the Collective Use Chemical Service Center of the Siberian Branch of the Russian Academy of Sciences for the spectral studies and analytical support.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk National Research State UniversityNovosibirskRussia

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