A novel series of spirochromone-flavonol derivatives were synthesized starting from a monospirochromone moiety using NaOH and H2O2 by a modified Algar–Flynn–Oyamada reaction. In this method, the title compounds were synthesized in good yields without isolating chalcones. The structures of the synthesized compounds have been established on the basis of physical and spectral data (IR, 1H, 13C NMR, and mass spectra). All the newly synthesized compounds were screened for in vitro antimicrobial activity. All the compounds were shown moderate to good antimicrobial activity.
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The authors are grateful to the Head of the Department of Chemistry, Osmania University, Hyderabad and JNTU Hyderabad for providing analytical facilities. The authors are thankful to Vishnu Chemicals limited, Jeedimetla and Department of Chemistry, Anurag group of Institutions, Hyderabad for providing laboratory facilities.
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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(11), 1187–1191
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Kishore, N.R., Ashok, D., Sarasija, M. et al. One-pot synthesis of spirochromanone-based 3-hydroxy-4H-chromen-4-ones by a modified Algar–Flynn–Oyamada reaction and evaluation of their antimicrobial activity. Chem Heterocycl Comp 53, 1187–1191 (2017). https://doi.org/10.1007/s10593-018-2200-7
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DOI: https://doi.org/10.1007/s10593-018-2200-7