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An efficient and facile synthesis of D-cycloserine substantially free from potential impurities

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Chemistry of Heterocyclic Compounds Aims and scope

An efficient and facile synthesis of D-cycloserine has been developed from D-serine with 61% overall yield employing protectiondeprotection strategy. Different parameters affecting the impurities content and yield of D-cycloserine have been studied. Mild reaction conditions provided the product with remarkable purity (>99%) and high stability.

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The authors acknowledge management of Micro Labs Ltd., Active Pharmaceutical Ingredients Research and Development Centre for providing research and analytical facilities.

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Authors and Affiliations

  1. Micro Labs Ltd., Chemical Research Department, API R&D Centre, 43-45 Bommasandra-Jigini Link Road, KIADB INDL Area, Bangalore, Karnataka, 560105, India

    Arun Kumar Awasthi, Brijesh Kumar, Mushtaq A Aga, Punit Tripathi & Pramod Kumar

  2. Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, 517502, India

    Arun Kumar Awasthi & Cirandur Suresh Reddy

Authors
  1. Arun Kumar Awasthi
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  2. Brijesh Kumar
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  3. Mushtaq A Aga
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  4. Punit Tripathi
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  5. Cirandur Suresh Reddy
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  6. Pramod Kumar
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Correspondence to Pramod Kumar.

Additional information

A Supplementary information file containing 1H and 13C NMR spectra and HPLC analysis of the synthesized compounds is available at the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(11), 1248–1253

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Awasthi, A.K., Kumar, B., Aga, M.A. et al. An efficient and facile synthesis of D-cycloserine substantially free from potential impurities. Chem Heterocycl Comp 53, 1248–1253 (2017). https://doi.org/10.1007/s10593-018-2197-y

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