An efficient protocol for the synthesis of a new series of 1H-pyrazolo[3,4-b]quinolines has been described. The target compounds have been synthesized by one-pot multicomponent reaction of aniline, aromatic aldehydes, and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one using L-proline as an organocatalyst. Structural diversity and high yields of products, broad scope of aromatic aldehydes, simple operation, and short reaction times have been demonstrated as the advantages of the developed synthetic approach.
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Authors are grateful to Manipal Institute of Technology for the laboratory facility and one of the authors acknowledges Manipal University for financial support under MU-structured PhD program.
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Supplementary information file, containing IR, 1H, 13C NMR spectra of selected compounds, is available at http://link.springer.com/journal/10593.
Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(8), 883–886
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Hegde, H., Shetty, N.S. Facile one-pot multicomponent synthesis of 1H-pyrazolo[3,4-b]quinolines using L-proline as a catalyst. Chem Heterocycl Comp 53, 883–886 (2017). https://doi.org/10.1007/s10593-017-2152-3
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DOI: https://doi.org/10.1007/s10593-017-2152-3