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Synthesis and biological activity of heterocyclic borneol derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

A series of novel heterocyclic derivatives of (–)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

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This work was supported by the Russian Foundation for Basic Research (grant No. 15-03-00193).

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Lavrentiev Ave, Novosibirsk, 630090, Russia

    Anastasiya S. Sokolova, Olga I. Yarovaya, Marina S. Borisova, Ekaterina A. Morozova, Tatyana G. Tolstikova & Nariman F. Salakhutdinov

  2. Novosibirsk State University, 2 Pirogova St, Novosibirsk, 630090, Russia

    Anastasiya S. Sokolova, Olga I. Yarovaya & Nariman F. Salakhutdinov

  3. Department of Chemotherapy, Research Institute of Influenza, 15/17 Prof. Popova St, Saint Petersburg, 197376, Russia

    Anna A. Shtro & Vladimir V. Zarubaev

Authors
  1. Anastasiya S. Sokolova
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  2. Olga I. Yarovaya
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  3. Anna A. Shtro
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  4. Marina S. Borisova
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  5. Ekaterina A. Morozova
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  6. Tatyana G. Tolstikova
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  7. Vladimir V. Zarubaev
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  8. Nariman F. Salakhutdinov
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Corresponding author

Correspondence to Anastasiya S. Sokolova.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(3), 371–377

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Sokolova, A.S., Yarovaya, O.I., Shtro, A.A. et al. Synthesis and biological activity of heterocyclic borneol derivatives. Chem Heterocycl Comp 53, 371–377 (2017). https://doi.org/10.1007/s10593-017-2063-3

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  • DOI: https://doi.org/10.1007/s10593-017-2063-3

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