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(5S,7R)-5-Aryl-7-methyl-4,5,6,7-tetrahydro-[1, 2, 4]triazolo[1,5-a]pyrimidin-7-ols as products of three-component condensation

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Chemistry of Heterocyclic Compounds Aims and scope

(5S,7R)-5-Aryl-7-methyl-4,5,6,7-tetrahydro[1, 2, 4]triazolo[1,5-a]pyrimidin-7-ols were synthesized by three-component reactions of 1H-1,2,4-triazol-3-amine with aromatic aldehydes and acetone in the presence of TsOH. Antimicrobial and antifungal activities of these new substances were investigated in vitro.

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Authors and Affiliations

  1. STC “The Institute for Single Crystals”, National Academy of Science of Ukraine, 60 Nauky Ave, Kharkiv, 61001, Ukraine

    Sergey A. Komykhov, Andrey A. Bondarenko, Vladimir I. Musatov, Nikolay Yu. Gorobets & Sergey M. Desenko

  2. Kharkiv National V. N. Karazin University, 4 Svobody Sq, Kharkiv, 61000, Ukraine

    Sergey A. Komykhov & Sergey M. Desenko

  3. Zaporizhzhia State Medical University, 26 Mayakovsky Ave, Zaporizhia, 69035, Ukraine

    Mikhail V. Diachkov

Authors
  1. Sergey A. Komykhov
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  2. Andrey A. Bondarenko
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  3. Vladimir I. Musatov
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  4. Mikhail V. Diachkov
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  5. Nikolay Yu. Gorobets
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  6. Sergey M. Desenko
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Corresponding author

Correspondence to Sergey A. Komykhov.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(3), 378–380

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Komykhov, S.A., Bondarenko, A.A., Musatov, V.I. et al. (5S,7R)-5-Aryl-7-methyl-4,5,6,7-tetrahydro-[1, 2, 4]triazolo[1,5-a]pyrimidin-7-ols as products of three-component condensation. Chem Heterocycl Comp 53, 378–380 (2017). https://doi.org/10.1007/s10593-017-2059-z

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  • DOI: https://doi.org/10.1007/s10593-017-2059-z

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