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Heterocycles as classical and nonclassical ring B isosters in combretastatin A-4

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Chemistry of Heterocyclic Compounds Aims and scope

The minireview provides a survey of combretastatin A-4 analogs, obtained by isosteric replacement of 3-hydroxy-4-methoxyphenyl ring (ring B) with various heterocyclic systems. The basic synthetic approaches and structure–activity relationships are summarized.

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The authors thank the Russian Foundation for Basic Research (project 15-03-04894) for support in providing an access to the full texts of the papers.

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Authors and Affiliations

  1. Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russia

    Nikolay A. Zefirov & Olga N. Zefirova

  2. Institute of Physiologically Active Compounds, Severny Proezd, 1, Chernogolovka, Moscow Region, 142432, Russia

    Olga N. Zefirova

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  1. Nikolay A. Zefirov
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  2. Olga N. Zefirova
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Correspondence to Olga N. Zefirova.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(3), 273–280

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Zefirov, N.A., Zefirova, O.N. Heterocycles as classical and nonclassical ring B isosters in combretastatin A-4. Chem Heterocycl Comp 53, 273–280 (2017). https://doi.org/10.1007/s10593-017-2049-1

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  • DOI: https://doi.org/10.1007/s10593-017-2049-1

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