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Synthesis of 5-chloro-7-azaindoles by Fischer reaction

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Chemistry of Heterocyclic Compounds Aims and scope

A simple and effective method on the basis of Fischer reaction in polyphosphoric acid is proposed for the synthesis of previously unknown heterocyclic structures that contain the 5-chloro-1H-pyrrolo[2,3-b]pyridine system. This method can be used for the synthesis of 3-substituted and 2,3-disubstituted 5-chloro-7-azaindoles with alkyl and aryl substituents.

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This work received financial support from the Russian Foundation for Basic Research (grant 14-03-31289).

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Authors and Affiliations

  1. Moscow M. V. Lomonosov State University, 1, Build. 3 Leninskie Gory, Moscow, 119991, Russia

    Roman S. Alekseyev & Vladimir I. Terenin

  2. Baku Branch of Moscow M. V. Lomonosov State University, 1 Universitetskaya St., Khojasan, Binagadi, Baku, AZ, 1144, Azerbaijan

    Sabina R. Amirova

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  1. Roman S. Alekseyev
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  2. Sabina R. Amirova
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  3. Vladimir I. Terenin
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Correspondence to Roman S. Alekseyev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(2), 196–206

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Alekseyev, R.S., Amirova, S.R. & Terenin, V.I. Synthesis of 5-chloro-7-azaindoles by Fischer reaction. Chem Heterocycl Comp 53, 196–206 (2017). https://doi.org/10.1007/s10593-017-2040-x

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  • DOI: https://doi.org/10.1007/s10593-017-2040-x

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