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Acid-catalyzed reaction of phenols with N-(4,4-diethoxybutyl)sulfonamides – a new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines

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Chemistry of Heterocyclic Compounds Aims and scope

We have developed a new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines on the basis of reactions between various phenols and N-(4,4-diethoxybutyl)sulfonamides in the presence of trifluoroacetic acid. The structures of the obtained products were confirmed by 1H and 13C NMR spectroscopy, IR spectroscopy, and X-ray structural analysis.

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The work was performed with financial support from the Russian Science Foundation (grant 16-13-10023).

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Akademika Arbuzova St, Kazan, 420088, Russia

    Andrey V. Smolobochkin, Almir S. Gazizov, Alexander R. Burilov & Michael A. Pudovik

  2. Kazan National Research Technological University, 68 Karla Marksa St, Kazan, 420015, Russia

    Ekaterina A. Anikina

Authors
  1. Andrey V. Smolobochkin
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  2. Almir S. Gazizov
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  3. Ekaterina A. Anikina
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  4. Alexander R. Burilov
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  5. Michael A. Pudovik
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Corresponding author

Correspondence to Almir S. Gazizov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(2), 161–166

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Smolobochkin, A.V., Gazizov, A.S., Anikina, E.A. et al. Acid-catalyzed reaction of phenols with N-(4,4-diethoxybutyl)sulfonamides – a new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines. Chem Heterocycl Comp 53, 161–166 (2017). https://doi.org/10.1007/s10593-017-2034-8

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  • DOI: https://doi.org/10.1007/s10593-017-2034-8

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