Chemistry of Heterocyclic Compounds

, Volume 52, Issue 11, pp 952–957 | Cite as

Preparation of benzimidazole N-oxides by a two-step continuous flow process

  • Fabrizio Politano
  • Elba I. Buján
  • Nicholas E. Leadbeater

A continuous flow process for the synthesis of nitrobenzimidazole N-oxides from 2,6-dinitrochlorobenzene and amines or amino acids is reported. The process, performed in a two-step sequence, is faster than previously reported batch processes and avoids some of the isolation and purification steps.


benzimidazoles N-oxides cyclization flow chemistry green chemistry nucleophilic aromatic substitution 


Fabrizio Politano is thankful to Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina, for a PhD fellowship and to Bec.Ar – Fulbright Commission, for an exchange fellowship.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Fabrizio Politano
    • 1
    • 2
  • Elba I. Buján
    • 2
  • Nicholas E. Leadbeater
    • 1
  1. 1.Department of ChemistryUniversity of ConnecticutStorrsUSA
  2. 2.Instituto de Investigaciones en Físico Química de Córdoba (INFIQC)-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad UniversitariaCórdobaArgentina

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