We report the first systematic study on the channel size effect in various microreactor systems on the efficiency of phase-transfercatalyzed azo coupling reactions. The optimum scaled-up channel diameter was 0.5 mm, which facilitated the synthesis of diazo compounds in high yields.
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The authors would like to acknowledge Nelson Mandela Metropolitan University and the National Research Foundation of South Africa for financial support.
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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(11), 943–947
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Akwi, F.M., Watts, P. Study on the Scale-Up of Phase-Transfer-Catalyzed Azo Coupling Reactions in Flow Reactors. Chem Heterocycl Comp 52, 943–947 (2016). https://doi.org/10.1007/s10593-017-1990-3
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DOI: https://doi.org/10.1007/s10593-017-1990-3