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Chemistry of Heterocyclic Compounds

, Volume 52, Issue 8, pp 555–558 | Cite as

Synthesis and cytotoxicity of aminomethylselenopheno[3,2-b]thiophene sulfonamides

  • Pavel ArsenyanEmail author
  • Kira Rubina
  • Ilona Domracheva
Article
  • 92 Downloads

The reaction of 5-[(aminomethyl)ethynyl]thiophene-2-sulfonamides with in situ generated selenium(IV) chloride was used to synthesize 5-aminomethyl-substituted 6-chloroselenopheno[3,2-b]thiophene-2-sulfonamides. The cytotoxicity of these compounds was studied against HT-1080 (human fibrosarcoma), MH-22A (mouse hepatoma), CCL-8 (mouse sarcoma), MES-SA (human uterine sarcoma), MCF-7 (estrogen receptor-positive human breast adenocarcinoma) cell lines, as well as the normal NIH 3T3 cell line (mouse fibroblasts).

Keywords

selenium selenophene sulfonamide thiophene cytotoxicity electrophilic addition intramolecular cyclization 

Notes

This work received financial support from the Latvian Council of Science (grant No. 2012/447).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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