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Chemistry of Heterocyclic Compounds

, Volume 52, Issue 8, pp 551–554 | Cite as

Selenium analogs of raloxifene: antioxidant activity endowed to an old drug

  • Ilona Domracheva
  • Anita Gulbe
  • Edgars Paegle
  • Pavel ArsenyanEmail author
Article
  • 60 Downloads

The antioxidant activity of selenium-containing analogs of raloxifene was studied by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and peroxyl radicals. These compounds exhibited similar scavenging properties as resveratrol with respect to superoxide radical and had an impressive activity in peroxyl radical scavenging, making them promising candidates for the development of antioxidant agents.

Keywords

raloxifene antioxidant peroxyl radical selenium selenophene superoxide radical 

Notes

The financial support of this work provided by the Latvian Council of Science (grant No. 447/2012) is gratefully acknowledged.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Ilona Domracheva
    • 1
  • Anita Gulbe
    • 1
  • Edgars Paegle
    • 1
  • Pavel Arsenyan
    • 1
    Email author
  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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