Chemistry of Heterocyclic Compounds

, Volume 52, Issue 8, pp 538–540 | Cite as

Ionic liquids, metal oxide nanoparticles, and enzymes in synthesis of 1,4-dihydropyridines (microreview)

  • Klavs Pajuste
  • Aiva PlotnieceEmail author
This microreview is devoted to the specific recent synthetic approaches toward 1,4-dihydropyridines which represent significant group of N-containing heterocycles due to the wide applications of their pharmacological activities. Mainly 1,4-dihydropyridines are synthesized in Hantzsch reaction and its modifications. Nowadays a number of strategies and various catalysts or catalytic systems have been developed to improve the yields of 1,4-dihydropyridines and to reduce chemical impact on environment. Here the contemporary synthetic aspects from last five years such as use of ionic liquids, metal oxide nanoparticles and some reports about enzymatic approaches are discussed.


Ionic Liquid Triflate Diethylene Glycol Pyrazolyl Metal Oxide Nanoparticles 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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