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Synthesis of 4-aryl-2-pyranyl-7,8-dihydroquinolin-5(6H)-ones catalyzed by cerium ammonium nitrate via Hantzsch multicomponent reaction and their antibacterial activity

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Chemistry of Heterocyclic Compounds Aims and scope

4-Aryl-2-pyranyl-7,8-dihydroquinolin-5(6H)-one derivatives were obtained in excellent yields from 3-acetyl-4-hydroxy-6-methyl-2Hpyran-2-one, aromatic aldehydes, 5,5-dimethylcyclohexane-1,3-dione, and ammonium acetate by a one-pot multicomponent Hantzsch synthesis in the presence of cerium ammonium nitrate in water. In vitro antibacterial activity of all the newly synthesized compounds was evaluated. Some of the tested compounds showed a promising antibacterial activity against both Gram-positive and Gram-negative bacterial strains.

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The authors are thankful to the Director, NIT Raipur for providing facilities. One of the authors (Gudala Satish) is thankful to the Director for awarding TEQIP Fellowship.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology, Raipur, G.E Road, Raipur, 492010, C.G., India

    Gudala Satish, Archi Sharma & Santhosh Penta

  2. Department of Biotechnology, Kakatiya University, Warangal, 506009, Telangana, India

    Kranthi Kumar Gadidasu

  3. Department of Chemistry, National Institute of Technology, Warangal, 506 004, Telangana, India

    Rajeswar Rao Vedula

Authors
  1. Gudala Satish
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  2. Archi Sharma
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  3. Kranthi Kumar Gadidasu
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  4. Rajeswar Rao Vedula
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  5. Santhosh Penta
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Corresponding author

Correspondence to Santhosh Penta.

Additional information

The Supplementary information file containing 1H and 13C NMR spectra of the synthesized compounds is available from the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(6), 409–414

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Satish, G., Sharma, A., Gadidasu, K.K. et al. Synthesis of 4-aryl-2-pyranyl-7,8-dihydroquinolin-5(6H)-ones catalyzed by cerium ammonium nitrate via Hantzsch multicomponent reaction and their antibacterial activity. Chem Heterocycl Comp 52, 409–414 (2016). https://doi.org/10.1007/s10593-016-1902-y

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  • DOI: https://doi.org/10.1007/s10593-016-1902-y

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