A new, highly efficient method was developed for the synthesis of (3-indolyl)acetonitriles by reduction of readily available (3-indolyl)hydroxamic acids with phosphorus trichloride. The nitriles obtained according to this method are of significant interest for structure-activity studies of potential anticancer agents.
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This study was performed with financial support from the Russian Science Foundation (grant No. 14-13-01108).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(5), 299–302
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Aksenov, A.V., Aksenov, N.A., Dzhandigova, Z.V. et al. An efficient synthesis of (3-indolyl)acetonitriles by reduction of hydroxamic acids. Chem Heterocycl Comp 52, 299–302 (2016). https://doi.org/10.1007/s10593-016-1881-z
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DOI: https://doi.org/10.1007/s10593-016-1881-z