A new series of 3-hydroxy-2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]-4H-chromen-4-ones has been synthesized from substituted 2-hydroxyacetophenones and 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde using NaOH and H2O2 by modified Algar–Flynn–Oyamada reaction under conventional and microwave irradiation conditions. In this method flavonols are synthesized without isolating chalcones in good yields (80–85%). The structures of the compounds were established on the basis of IR, 1H, 13C NMR and mass spectral and elemental analysis data. The synthesized compounds were screened for their antibacterial and antifungal activities.
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Supplementary information file to this article containing IR, 1H, 13C NMR and mass spectra of the synthesized compounds is available online at http://link.springer.com/journal/10593.
Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(3), 172–176
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Ashok, D., Kifah, M.A., Lakshmi, B.V. et al. Microwave-assisted one-pot synthesis of some new flavonols by modified Algar–Flynn–Oyamada reaction and their antimicrobial activity. Chem Heterocycl Comp 52, 172–176 (2016). https://doi.org/10.1007/s10593-016-1852-4
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DOI: https://doi.org/10.1007/s10593-016-1852-4