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Alkylation of 5-aryltetrazoles with 2- and 4-hydroxybenzyl alcohols

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of salicylic alcohol with 5-aryltetrazoles gave mixtures of 2-[(5-aryl-1H-tetrazol-1-yl)methyl]- and 2-[(5-aryl-2H-tetrazol-2-yl)methyl]phenols. In the case of other ortho- and para-hydroxybenzyl alcohols, 2,5-disubstituted products were formed selectively. The criteria for detecting 1,5- and 2,5-disubstituted N-benzyltetrazoles by standard 1Н and 13С NMR spectroscopy have been identified.

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Authors and Affiliations

  1. Samara State Technical University, 244 Molodogvardeiskaya St., Samara, 443100, Russia

    Vitaly A. Osyanin, Dmitry V. Osipov, Vitaly Yu. Nakushnov, Margarita N. Zemtsova & Yuri N. Klimochkin

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  1. Vitaly A. Osyanin
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  2. Dmitry V. Osipov
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  3. Vitaly Yu. Nakushnov
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  4. Margarita N. Zemtsova
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  5. Yuri N. Klimochkin
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Correspondence to Vitaly A. Osyanin.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(11/12), 984–990

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Osyanin, V.A., Osipov, D.V., Nakushnov, V.Y. et al. Alkylation of 5-aryltetrazoles with 2- and 4-hydroxybenzyl alcohols. Chem Heterocycl Comp 51, 984–990 (2015). https://doi.org/10.1007/s10593-016-1808-8

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  • DOI: https://doi.org/10.1007/s10593-016-1808-8

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