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Novel 3-acetyl-2-methyl-polyfluorochromones in reactions with amines and esters of amino acids

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Chemistry of Heterocyclic Compounds Aims and scope

Novel 3-acetyl-2-methyl-polyfluoro-4Н-chromen-4-ones were obtained via one-pot acylation of acetylacetone with polyfluorobenzoyl chlorides. These chromones were shown to form N-substituted 3-amino-1-[2-hydroxy(polyfluoro)phenyl]but-2-en-1-ones in reaction with aliphatic primary amines, esters of amino acids, and aqueous ammonia via opening of the pyrone ring and deacylation.

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Authors and Affiliations

  1. I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch of Russain Academy of Sciences, 22 S. Kovalevskoi St. / 20 Akademicheskaya St., Yekaterinburg, 620990, Russia

    Konstantin V. Shcherbakov, Denis N. Bazhin, Yanina V. Burgart & Victor I. Saloutin

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  1. Konstantin V. Shcherbakov
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  2. Denis N. Bazhin
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  3. Yanina V. Burgart
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  4. Victor I. Saloutin
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Correspondence to Konstantin V. Shcherbakov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(11/12), 961–968

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Shcherbakov, K.V., Bazhin, D.N., Burgart, Y.V. et al. Novel 3-acetyl-2-methyl-polyfluorochromones in reactions with amines and esters of amino acids. Chem Heterocycl Comp 51, 961–968 (2015). https://doi.org/10.1007/s10593-016-1805-y

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