Reversible condensation of 4-arylidene-1,2-dimethyl-1H-imidazol-5(4H)-ones with aromatic acyl chlorides
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(Z)-1,2-Dimethyl-4-(4-methoxybenzylidene)-1H-imidazol-5(4H)-one underwent a condensation reaction with aromatic acyl chlorides, forming keto derivatives that were structurally similar to chromophores of red fluorescent proteins, as well as to the products of their maturation and/or degradation. The reverse reaction of the obtained products was observed upon treatment with aqueous alkali.
Keywordsimidazolones chromophores fluorescent proteins condensation
The study was performed with financial support from the Russian Foundation for Basic Research in the framework of the project No. 14-50-00131. The equipment of Collective Use Center of the Institute of Bioorganic Chemistry was used for part of this research.
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