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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 10, pp 936–939 | Cite as

New domino dimerization of cyclopropylindoles: synthesis of 1,3-bis(indolyl)cyclopentanes

  • Olga А. Ivanova
  • Ekaterina M. Budynina
  • Victor N. Khrustalev
  • Igor V. TrushkovEmail author
  • Mikhail Ya. Melnikov
Article
The diester of 2-(1-benzyl-2-methylindol-3-yl)cyclopropane-1,1-dicarboxylic acid undergoes a domino reaction in the presence of titanium(IV) chloride, forming an unusual [3+2] cyclodimer, 1,3-bis(indolyl)cyclopentane.

Keywords

donor-acceptor cyclopropanes indole Lewis acids dimerization 

Notes

The work was performed with financial support from the Russian Scientific Fund (grant 14-13-01178).

Supplementary material

10593_2015_1798_MOESM1_ESM.pdf (424 kb)
Supplementary Information file (PDF 423 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Olga А. Ivanova
    • 1
    • 2
  • Ekaterina M. Budynina
    • 1
    • 2
  • Victor N. Khrustalev
    • 3
    • 4
  • Igor V. Trushkov
    • 1
    • 2
    Email author
  • Mikhail Ya. Melnikov
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after D. RogachevMoscowRussia
  3. 3.A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences,MoscowRussia
  4. 4.Peoples’ Friendship University of RussiaMoscowRussia

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