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Green and Catalyst-free One-pot Synthesis Of 2,3-dihydroquinazolin-4(1h)-ones in Water

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Chemistry of Heterocyclic Compounds Aims and scope

A facile and highly efficient protocol was successfully applied to synthesize mono- and disubstituted dihydroquinazolinones through a three-component coupling reaction of isatoic anhydride, aniline or ammonium acetate, and aromatic aldehydes in refluxing water with excellent yield without using any catalysts. The protocol avoids the use of hazardous solvents and chromatographic separation. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.

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The authors thank the Research Council of Payame Noor University for financial support.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, PO BOX 19395–3697, Tehran, Iran

    Abolfazl Olyaei & Fatemeh Rahbarian

  2. Department of Chemistry, College of Science, Takestan Branch, Islamic Azad University, Takestan, Iran

    Mahdieh Sadeghpour

Authors
  1. Abolfazl Olyaei
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  2. Fatemeh Rahbarian
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  3. Mahdieh Sadeghpour
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Correspondence to Abolfazl Olyaei or Mahdieh Sadeghpour.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(10), 899–902

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Olyaei, A., Rahbarian, F. & Sadeghpour, M. Green and Catalyst-free One-pot Synthesis Of 2,3-dihydroquinazolin-4(1h)-ones in Water. Chem Heterocycl Comp 51, 899–902 (2015). https://doi.org/10.1007/s10593-015-1793-3

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