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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 10, pp 899–902 | Cite as

Green and Catalyst-free One-pot Synthesis Of 2,3-dihydroquinazolin-4(1h)-ones in Water

  • Abolfazl OlyaeiEmail author
  • Fatemeh Rahbarian
  • Mahdieh SadeghpourEmail author
Article
A facile and highly efficient protocol was successfully applied to synthesize mono- and disubstituted dihydroquinazolinones through a three-component coupling reaction of isatoic anhydride, aniline or ammonium acetate, and aromatic aldehydes in refluxing water with excellent yield without using any catalysts. The protocol avoids the use of hazardous solvents and chromatographic separation. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.

Keywords

aromatic aldehyde dihydroquinazolinone isatoic anhydride 

Notes

The authors thank the Research Council of Payame Noor University for financial support.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of ChemistryPayame Noor UniversityTehranIran
  2. 2.Department of Chemistry, College of Science, Takestan BranchIslamic Azad UniversityTakestanIran

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