Microwave-assisted synthesis and antimicrobial evaluation of novel pyrazolines
- 118 Downloads
A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.
Keywordschalcones pyrazolines antimicrobial activity Michael addition microwave irradiation
We thank the Head of Department of Chemistry, Osmania University, Hyderabad, for providing laboratory facilities. One of the authors (MGD) is grateful to University Grants Commission, New Delhi, for the award of Senior Research Fellowship. We also thank the CFRD analytical team, Osmania University, for providing spectral analysis facilities.
- 1.Williams, D. A.; Lemke, T. L. Foye's Principles of Medicinal Chemistry; 5th ed.; Lippincott Williams and Wilkins, 2002, p. 275.Google Scholar
- 20.Rajani, P.; Ashok, D.; Sharma, P. N. J. Indian Chem. Soc. 1990, 67, 854.Google Scholar
- 24.Murthy, Y. L. N.; Surya Prabha, R.; Seetharam, S. Indian J. Chem. 2004, 43B, 361.Google Scholar
- 25.Meth-Cohn, O.; Narine, B.; Tarnowski, B. A. J. Chem. Soc., Perkin Trans. 1 1981, 1520.Google Scholar
- 26.Amir, M.; Kumar, S. Indian J. Chem. 2005, 44B, 2532.Google Scholar
- 27.Aggarwal, R.; Kumar, V.; Singh, S. P. Indian J. Chem. 2007, 46B, 1332.Google Scholar
- 31.Barry, A. L.; Coyle, M. B.; Thornsberry, C.; Gerlach, E. H.; Hawkinson, R. W. J. Clin. Microbiol. 1979, 10, 885.Google Scholar