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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 10, pp 872–882 | Cite as

Microwave-assisted synthesis and antimicrobial evaluation of novel pyrazolines

  • Ashok DongamantiEmail author
  • Mohan Gandhi Devulapally
  • Vikas Kumar Aamate
  • Srinivas Gundu
Article

A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.

Keywords

chalcones pyrazolines antimicrobial activity Michael addition microwave irradiation 

Notes

We thank the Head of Department of Chemistry, Osmania University, Hyderabad, for providing laboratory facilities. One of the authors (MGD) is grateful to University Grants Commission, New Delhi, for the award of Senior Research Fellowship. We also thank the CFRD analytical team, Osmania University, for providing spectral analysis facilities.

Supplementary material

10593_2015_1790_MOESM1_ESM.pdf (5.8 mb)
Supporting material (PDF 5911 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Ashok Dongamanti
    • 1
    Email author
  • Mohan Gandhi Devulapally
    • 1
  • Vikas Kumar Aamate
    • 1
  • Srinivas Gundu
    • 1
  1. 1.Department of ChemistryOsmania UniversityHyderabadIndia

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