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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 9, pp 858–860 | Cite as

A novel synthesis of (E)-1-(2-hydroxyphenyl)-3-(1Н-indol-3-yl)- prop-2-en-1-ones from chromone-3-carboxylic acid and indoles

  • Mikhail Yu. Kornev
  • Vladimir S. Moshkin
  • Vyacheslav Ya. Sosnovskikh
LETTERS TO THE EDITOR
The reaction of chromone-3-carboxylic acid with indoles in boiling ethanol proceeds as a 1,4-nucleophilic addition with successive opening of the pyrone ring and decarboxylation to afford a series of previously unknown trans-indolyl chalcones in 27–60% yields.

Keywords

chromone-3-carboxylic acid indolyl chalcones indoles Michael addition 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Mikhail Yu. Kornev
    • 1
  • Vladimir S. Moshkin
    • 1
  • Vyacheslav Ya. Sosnovskikh
    • 1
  1. 1.Institute of Natural SciencesUral Federal University named after the First President of Russia B. N. YeltsinYekaterinburgRussia

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