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A novel synthesis of (E)-1-(2-hydroxyphenyl)-3-(1Н-indol-3-yl)- prop-2-en-1-ones from chromone-3-carboxylic acid and indoles

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of chromone-3-carboxylic acid with indoles in boiling ethanol proceeds as a 1,4-nucleophilic addition with successive opening of the pyrone ring and decarboxylation to afford a series of previously unknown trans-indolyl chalcones in 27–60% yields.

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Notes

  1. Kornev, M. Yu.; Moshkin, V. S.; Sosnovskikh, V. Ya. Mendeleev Commun., in press.

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Authors and Affiliations

  1. Institute of Natural Sciences, Ural Federal University named after the First President of Russia B. N. Yeltsin, 51 Lenina Ave, Yekaterinburg, 620000, Russia

    Mikhail Yu. Kornev, Vladimir S. Moshkin & Vyacheslav Ya. Sosnovskikh

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  1. Mikhail Yu. Kornev
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  2. Vladimir S. Moshkin
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  3. Vyacheslav Ya. Sosnovskikh
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Correspondence to Vyacheslav Ya. Sosnovskikh.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(9), 858–860

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Kornev, M.Y., Moshkin, V.S. & Sosnovskikh, V.Y. A novel synthesis of (E)-1-(2-hydroxyphenyl)-3-(1Н-indol-3-yl)- prop-2-en-1-ones from chromone-3-carboxylic acid and indoles. Chem Heterocycl Comp 51, 858–860 (2015). https://doi.org/10.1007/s10593-015-1786-2

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  • DOI: https://doi.org/10.1007/s10593-015-1786-2

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