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Synthesis, characterization, and antibacterial evaluation of new alkyl 2-amino-4-aryl-4H-chromene-3-carboxylates

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Chemistry of Heterocyclic Compounds Aims and scope

A series of alkyl 2-amino-4-aryl-4H-chromene-3-carboxylates was synthesized by an efficient, solvent-free one-pot three-component cyclocondensation of resorcinol, aromatic aldehydes, and ethyl or methyl cyanoacetate using sodium carbonate as catalyst. The present methodology offers several advantages, such as a simple procedure with ease of handling, short reaction time, high yields, and the absence of any volatile and hazardous organic solvents. The products were characterized on the basis of IR, 1H NMR, and 13C NMR spectral and microanalytical data and evaluated for their antibacterial activity against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) using paper disc diffusion technique.

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The authors express their gratitude to the Islamic Azad University, Mashhad Branch for its financial support.

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Authors and Affiliations

  1. Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, 91735-413, Iran

    Sedighe Gholipour & Abolghasem Davoodnia

  2. Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, 91735-413, Iran

    Mahboobeh Nakhaei-Moghaddam

Authors
  1. Sedighe Gholipour
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  2. Abolghasem Davoodnia
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  3. Mahboobeh Nakhaei-Moghaddam
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Correspondence to Abolghasem Davoodnia.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(9), 808–813

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Gholipour, S., Davoodnia, A. & Nakhaei-Moghaddam, M. Synthesis, characterization, and antibacterial evaluation of new alkyl 2-amino-4-aryl-4H-chromene-3-carboxylates. Chem Heterocycl Comp 51, 808–813 (2015). https://doi.org/10.1007/s10593-015-1779-1

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