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Synthesis of 2-amino-4H-1,3-oxazines and 2-amino-4H-1,3-thiazines through a Yb(OTf)3-assisted, acid-catalyzed one-pot cyclocondensation reaction

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Chemistry of Heterocyclic Compounds Aims and scope

An efficient synthesis of 2-amino-4,6-diaryl-4H-1,3-oxazine and 2-amino-4,6-diaryl-4H-1,3-thiazine derivatives has been demonstrated through a one-pot multicomponent cyclocondensation reaction. Ytterbium triflate and concentrated HCl has been utilized as the catalyst system for this reaction. The method produced good to excellent product yields and allowed a wide variation of the substituents in both aryl moieties.

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We gratefully acknowledge financial supports from Science and Engineering Research Board, DST, Goverment of India (SERB No.SR/FT/CS-116/2010) to AC and UGC for SRF fellowship to SP.

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Authors and Affiliations

  1. Department of Chemistry, Maulana Azad College, Kolkata, -700013, India

    Salil Putatunda & Arijit Chakraborty

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  1. Salil Putatunda
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  2. Arijit Chakraborty
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Correspondence to Arijit Chakraborty.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(8), 763–768

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Putatunda, S., Chakraborty, A. Synthesis of 2-amino-4H-1,3-oxazines and 2-amino-4H-1,3-thiazines through a Yb(OTf)3-assisted, acid-catalyzed one-pot cyclocondensation reaction. Chem Heterocycl Comp 51, 763–768 (2015). https://doi.org/10.1007/s10593-015-1770-x

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