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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 8, pp 738–744 | Cite as

Synthesis of purine and 2-aminopurine conjugates bearing the fragments of heterocyclic amines at position 6

  • Dmitry A. Gruzdev
  • Vera V. Musiyak
  • Evgeny N. Chulakov
  • Galina L. Levit
  • Victor P. Krasnov
Article

A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.

Keywords

2-amino-6-chloropurine 6-chloropurine aromatic nucleophilic substitution catalysis heterocyclic amines 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Dmitry A. Gruzdev
    • 1
  • Vera V. Musiyak
    • 1
  • Evgeny N. Chulakov
    • 1
  • Galina L. Levit
    • 1
  • Victor P. Krasnov
    • 1
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesYekaterinburgRussia

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