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A novel method for the synthesis of imidazo[1,5-b]pyridazines

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Chemistry of Heterocyclic Compounds Aims and scope

Condensation of 4-phenylimidazole-1,2-diamine with 1-aryl-3-(dimethylamino)-2-propen-1-ones leads to the formation of 4-aryl-5-phenylimidazo[1,5-b]pyridazin-7-amines, which smoothly react at the exocyclic amino group with acetic anhydride, phenyl isocyanate, and para-tolualdehyde.

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Scheme 2

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This work was carried out with support from the Ministry of Education and Science of Russia within the framework of State Assignment to universities in the field of scientific activity for the 2014–2016 period: Project № 4.2100.2014/K (synthesis), № 1546 (X-ray structural analysis and spectral characterization).

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  1. Voronezh State University, 1 Universitetskaya Sq., Voronezh, 394006, Russia

    Dmitriy Yu. Vandyshev, Khidmet S. Shikhaliyev, Andrei Yu. Potapov & Mikhail Yu. Krysin

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  1. Dmitriy Yu. Vandyshev
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  2. Khidmet S. Shikhaliyev
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  3. Andrei Yu. Potapov
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  4. Mikhail Yu. Krysin
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Correspondence to Dmitriy Yu. Vandyshev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(6), 573–577

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Vandyshev, D.Y., Shikhaliyev, K.S., Potapov, A.Y. et al. A novel method for the synthesis of imidazo[1,5-b]pyridazines. Chem Heterocycl Comp 51, 573–577 (2015). https://doi.org/10.1007/s10593-015-1738-x

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