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Amides of 1,3,7-triazapyrene series: synthesis by nucleophilic substitution of alkoxy groups

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Chemistry of Heterocyclic Compounds Aims and scope

The treatment of 6,8-dialkoxy-1,3,7-triazapyrenes with sodium acylamides in DMSO at room temperature resulted in ipso substitution of one alkoxy group with amide group, giving 8-acylamino-6-alkoxy-1,3,7-triazapyrenes. The reaction at 65–70°C proceeded as a tandem SNAripso–SN2 process, leading to the formation of 8-acylamino-6-oxo-6,7-dihydro-1,3,7-triazapyrenes.

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This work received financial support from the Ministry of Education and Science of the Russian Federation (project No. 4.141.2014/K).

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Authors and Affiliations

  1. North-Caucasus Federal University, 1a Pushkina St., Stavropol, 355009, Russia

    Ivan V. Borovlev, Oleg P. Demidov, Nadezhda A. Kurnosova, Gulminat A. Amangazieva & Elena K. Avakyan

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  1. Ivan V. Borovlev
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  2. Oleg P. Demidov
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  3. Nadezhda A. Kurnosova
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  4. Gulminat A. Amangazieva
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  5. Elena K. Avakyan
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Correspondence to Ivan V. Borovlev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(4), 334–339

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Borovlev, I.V., Demidov, O.P., Kurnosova, N.A. et al. Amides of 1,3,7-triazapyrene series: synthesis by nucleophilic substitution of alkoxy groups. Chem Heterocycl Comp 51, 334–339 (2015). https://doi.org/10.1007/s10593-015-1704-7

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  • DOI: https://doi.org/10.1007/s10593-015-1704-7

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