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Rearrangement of oxazolo[3,2-a]pyridines as an approach of synthesizing aza[3.3.2]cyclazines

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Chemistry of Heterocyclic Compounds Aims and scope

5-Methyloxazolo[3,2-a]pyridinium salts were shown to react with (methylamino)acetaldehyde dimethyl acetal leading to the formation of functionalized 5-aminoindolizines, which in turn are capable of closing the pyrimidine ring in acidic media forming aza[3.3.2] cyclazines.

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This work was supported financially by the Russian Foundation for Basic Research (grant 12-03-00644-а) and by the Megagrant program (grant 2012-220-03-360).

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  1. Lomonosov Moscow State University, 1, Build. 3 Leninskie Gory, Moscow, 119991, Russia

    Eugene V. Babaev, Aleksandra A. Nevskaya & Ilya V. Dlynnikh

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  1. Eugene V. Babaev
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  2. Aleksandra A. Nevskaya
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  3. Ilya V. Dlynnikh
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Correspondence to Eugene V. Babaev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(3), 269–274

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Babaev, E.V., Nevskaya, A.A. & Dlynnikh, I.V. Rearrangement of oxazolo[3,2-a]pyridines as an approach of synthesizing aza[3.3.2]cyclazines. Chem Heterocycl Comp 51, 269–274 (2015). https://doi.org/10.1007/s10593-015-1685-6

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