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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 1, pp 102–106 | Cite as

An efficient solventless synthesis of cycloalkeno-1,2,3-selenadiazoles, their antimicrobial studies, and comparison with parent semicarbazones

  • Aditi A. Jadhav
  • Vaishali P. Dhanwe
  • Prasad G. Joshi
  • Pawan K. Khanna
Article

A series of heterocyclic organoselenium compounds, cycloalkeno-1,2,3-selenadiazoles (cyclopenteno, cyclohexeno, cyclohepteno, and cycloocteno-1,2,3-selenadiazoles), was synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. The synthesized 1,2,3-selenadiazoles and their parent semicarbazones were screened for their antimicrobial activity against various pathogenic bacteria using agar disc diffusion method. All compounds were found active against E. coli, S. aureus, S. typhi, and P. aeruginosa. Among all the tested selenadiazoles, cyclopenteno-1,2,3-selenadiazole showed excellent inhibition against highly resistant P. aeruginosa. It is observed that selenadiazoles showed higher activity compared with the respective semicarbazones.

Keywords

organoselenium compounds selenadiazoles semicarbazones grinding solventless synthesis 

Notes

Aditi A. Jadhav thanks Vice Chancellor (DIAT) for financial support and CDRI, Lucknow for providing NMR spectra. P. K. Khanna thanks DST, Govt. of India for research grant through project No. SR/S1/PC-39/2010. We are thankful to Padmaja Aerobiologicals (P) Ltd., Navi Mumbai for conducting antibacterial studies. We thank Dr. Priyesh More for fruitful discussion.

Supplementary material

10593_2015_1666_MOESM1_ESM.pdf (424 kb)
ESM 1 (PDF 423 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Aditi A. Jadhav
    • 1
  • Vaishali P. Dhanwe
    • 1
  • Prasad G. Joshi
    • 1
  • Pawan K. Khanna
    • 1
  1. 1.Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of IndiaPuneIndia

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