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Synthesis, characterization, and antimicrobial activity of benzimidazole-derived chalcones containing 1,3,4-oxadiazole moiety

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Chemistry of Heterocyclic Compounds Aims and scope

A series of novel benzimidazole-derived chalcones containing the 1,3,4-oxadiazole moiety were synthesized and characterized by IR, 1H, 13C NMR, and mass spectra and elemental analysis. The synthesized compounds were evaluated for their efficiency as antibacterial agents against two Gram-positive and Gram-negative strains of bacteria along with antifungal activity against three fungal species. Antibacterial activity revealed that tested compounds exhibited potent activity whereas some compounds exhibited moderate antifungal activity as compared to the standards.

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Authors are thankful to the Head, Department of Chemistry, University of Mumbai for providing research facilities. Authors are also grateful to UGC, New Delhi for providing the Research Fellowship in Sciences for Meritorious Students. We also express our sincere thanks to Dr. Dhanji P. Rajani, Microcare Laboratory, Surat, for availing the antimicrobial screening facilities for the compounds reported herein.

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Authors and Affiliations

  1. Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (East), Mumbai, 400098, India

    Gangadhar A. Meshram & Vipul A. Vala

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  1. Gangadhar A. Meshram
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  2. Vipul A. Vala
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Correspondence to Gangadhar A. Meshram.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(1), 44–50

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Supporting material to this article containing 1H and 13C NMR spectra compounds 9a–m are available for the authorized users.

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Meshram, G.A., Vala, V.A. Synthesis, characterization, and antimicrobial activity of benzimidazole-derived chalcones containing 1,3,4-oxadiazole moiety. Chem Heterocycl Comp 51, 44–50 (2015). https://doi.org/10.1007/s10593-015-1653-1

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  • DOI: https://doi.org/10.1007/s10593-015-1653-1

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