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Synthesis and Antioxidant Activity of Some New Heterocycles Incorporating the Pyrazolo-[3,4-D]Pyrimidin-4-One Moiety

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Chemistry of Heterocyclic Compounds Aims and scope

2-(4-Oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)acetonitrile was used as the key intermediate for the synthesis of polyfunctionally substituted heterocycles (e.g., pyrazoles, pyridine, tetrazole, thiazoles, thiophenes, and chromene) incorporating the pyrazolo[3,4-d]pyrimidin-4-one moiety. Representative compounds of the synthesized series were tested and evaluated as antioxidants. Two of the tested compounds (pyrazole and thiophene derivatives) showed antioxidant activity nearly equal to that of ascorbic acid.

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The author is grateful to Mr. A. Abass, Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Egypt, for performing the antioxidant activity analysis.

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Authors and Affiliations

  1. Faculty of Science, Mansoura University, El-Gomhoria St., Mansoura, 35516, Egypt

    A. El-Mekabaty

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  1. A. El-Mekabaty
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Correspondence to A. El-Mekabaty.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1847-1856, December, 2014.

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El-Mekabaty, A. Synthesis and Antioxidant Activity of Some New Heterocycles Incorporating the Pyrazolo-[3,4-D]Pyrimidin-4-One Moiety. Chem Heterocycl Comp 50, 1698–1706 (2015). https://doi.org/10.1007/s10593-015-1640-6

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  • DOI: https://doi.org/10.1007/s10593-015-1640-6

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