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Facile and Rapid Synthesis of 5-Substituted 1H-Tetrazoles VIA a Multicomponent Domino Reaction Using Nickel(II) Oxide Nanoparticles as Catalyst

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Chemistry of Heterocyclic Compounds Aims and scope

2-(1H-Tetrazol-5-yl)acrylonitrile derivatives were synthesized through multicomponent domino Knoevenagel condensation/1,3-dipolar cycloaddition reaction of carbonyl compounds, malononitrile, and sodium azide in the presence of NiO nanoparticles as a highly efficient catalyst. This method has the advantage of very short reaction times, high yields, simple methodology, and easy work-up. The catalyst can be recovered and reused while maintaining good yields.

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The authors gratefully acknowledge the partial financial support of this work by the University of Kashan Research Council by Grant No. 159196/XIX.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, P.O. Box 87317–51167, Kashan, I. R, Iran

    J. Safaei-Ghomi & S. Paymard-Samani

Authors
  1. J. Safaei-Ghomi
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  2. S. Paymard-Samani
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Correspondence to J. Safaei-Ghomi.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1706–1713, November, 2014.

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Safaei-Ghomi, J., Paymard-Samani, S. Facile and Rapid Synthesis of 5-Substituted 1H-Tetrazoles VIA a Multicomponent Domino Reaction Using Nickel(II) Oxide Nanoparticles as Catalyst. Chem Heterocycl Comp 50, 1567–1574 (2015). https://doi.org/10.1007/s10593-014-1625-x

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